Juvenile polyp

Juvenile polyp 

Updated: 03/02/2021

© Jun Wang, MD, PhD

General features
  • AKA retention polyp
  • Most common childhood polyp
  • May be seen in any age
  • Hamartomatous polyp
  • More common in rectum, can be seen in other parts of GI tract
  • Usually sporadic, may be associated with juvenile polyposis syndrome
  • May be associated with dysplasia, especially juvenile polyposis
Juvenile polyposis
  • Autosomal dominant
  • Loss of function mutation of SMAD4 and BMPR1A of TGF-β signaling pathway in juvenile polyposis
  • Multiple hamartomatous polyps
  • Increased risk for colorectal and stomach cancer
Key pathogenesis
  • Inflammation and regeneration
Clinical presentations
  • Usually asymptomatic
  • Most common symptom: hemorrhage
  • Others: prolapse, anemia, etc
Key morphological features

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