Pilomatricoma
Pilomatricoma
Updated: 03/28/2019
© Jun Wang, MD, PhD
General
features
- AKA pilomatrixoma, calcified epithelioma of Malherbe
- Most benign
- Arising from hair matrix
- Usually children and young adults in head, neck or upper extremities
- Likely associated with CTNNB (beta-catenin) mutation or bcl-2 overexpression
- Aggressive pilomatrixoma: Atypical histology, locally invasive with local recurrence
- Malignant pilomatrixoma: Cytologic atypia, infiltrative border, transition to squamous cells, necrosis, local recurrence and metastasize
Clinical
features
Pathological
features
- Solid nests of basaloid cells
- Abrupt keratinization
- Ghost cells, often foreign body reaction, calcification or ossification
Management
- Excision
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