Sebaceous adenoma

Sebaceous adenoma 

Updated: 02/15/2021

© Jun Wang, MD, PhD

General features
  • Associated with Muir-Torre Syndrome
Muir-Torre syndrome
  • Combination of neoplasms of the skin (usually sebaceous adenoma, sebaceous epithelioma, or sebaceous carcinoma but also keratoacanthoma) and a visceral malignancy (usually colorectal, endometrial, small intestine, and urothelial)
  •  Commonly autosomal dominant
  • Considered a subtype of Lynch syndrome
  • Associated with DNA mismatch repair gene (MMR), which leads to microsatellite instability, most commonly with MSH2
  • Clinical signs suggestive of Muir-Torre syndrome
Family or personal history of Lynch-related cancers
One or more sebaceous tumors
Age younger than 60 years at first presentation of sebaceous tumors
Clinical features
Pathological features
Management
  • Excision
  • Monitoring for recurrence
  • Consultation for underlying tumor



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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