Sebaceous adenoma

Sebaceous adenoma 

Updated: 02/15/2021

© Jun Wang, MD, PhD

General features
  • Associated with Muir-Torre Syndrome
Muir-Torre syndrome
  • Combination of neoplasms of the skin (usually sebaceous adenoma, sebaceous epithelioma, or sebaceous carcinoma but also keratoacanthoma) and a visceral malignancy (usually colorectal, endometrial, small intestine, and urothelial)
  •  Commonly autosomal dominant
  • Considered a subtype of Lynch syndrome
  • Associated with DNA mismatch repair gene (MMR), which leads to microsatellite instability, most commonly with MSH2
  • Clinical signs suggestive of Muir-Torre syndrome
Family or personal history of Lynch-related cancers
One or more sebaceous tumors
Age younger than 60 years at first presentation of sebaceous tumors
Clinical features
Pathological features
Management
  • Excision
  • Monitoring for recurrence
  • Consultation for underlying tumor



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