Sebaceous adenoma
Sebaceous adenoma
Updated: 02/15/2021
© Jun Wang, MD, PhD
General
features
- Associated with Muir-Torre Syndrome
Muir-Torre syndrome
- Combination of neoplasms of the skin (usually sebaceous adenoma, sebaceous epithelioma, or sebaceous carcinoma but also keratoacanthoma) and a visceral malignancy (usually colorectal, endometrial, small intestine, and urothelial)
- Commonly autosomal dominant
- Considered a subtype of Lynch syndrome
- Associated with DNA mismatch repair gene (MMR), which leads to microsatellite instability, most commonly with MSH2
- Clinical signs suggestive of Muir-Torre syndrome
Family or
personal history of Lynch-related cancers
One or more
sebaceous tumors
Age younger
than 60 years at first presentation of sebaceous tumors
Clinical
features
- Papule/nodule on face/scalp
Pathological
features
- Hyperplasia of sebaceous lobules
- Lobulated growth of generative cells (dark) and sebaceous cells (light)
- Cytoplasmic lipid vacuoles
Management
- Excision
- Monitoring for recurrence
- Consultation for underlying tumor
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