Seborrheic keratosis

Seborrheic keratosis
Updated: 03/27/2019
© Jun Wang, MD, PhD

General features
  • Benign epidermal proliferation
  • Most common benign tumor in elder population
  • Unclear etiology
  • Less common in people with darker skin
  • May harbor FGFR3 mutation
  • Squamous cell carcinoma or melanoma may arise
Clinical features
Leser-Trélat sign
  • Sudden appearance or increase in number and size of seborrheic keratosis
  • Associated with internal malignancy
  • Probably paraneoplastic phenomenon
  • More commonly associated with GI malignancy
Pathological features
Management
  • Removal


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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