Seborrheic keratosis

Seborrheic keratosis
Updated: 03/27/2019
© Jun Wang, MD, PhD

General features
  • Benign epidermal proliferation
  • Most common benign tumor in elder population
  • Unclear etiology
  • Less common in people with darker skin
  • May harbor FGFR3 mutation
  • Squamous cell carcinoma or melanoma may arise
Clinical features
Leser-Trélat sign
  • Sudden appearance or increase in number and size of seborrheic keratosis
  • Associated with internal malignancy
  • Probably paraneoplastic phenomenon
  • More commonly associated with GI malignancy
Pathological features
Management
  • Removal


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