Practice questions Lymphoid neoplasms IV
Practice questions Lymphoid neoplasms IV © Jun Wang, MD, PhD 1. Use this case and image for the next three questions. A 9-year-old boy presents to the clinic with a rapidly growing mass on his left face for the last 3 weeks. He has had intermittent night sweat, fatigue and a 9-lb weight loss during this period. Physical examination reveals a 7 cm poorly circumscribed firm mass on the left mandible. No other abnormality is noted. His CBC reveals a hemoglobin of 10.5 g/dL (11-13.5 g/dL). His WBC and platelet counts are within normal range. Peripheral blood smear reveals no significant morphological abnormalities of the blood cells. An image of his biopsy is shown. (Image credit: Ed Uthman, MD., CC BY 2.0 <https://creativecommons.org/licenses/by/2.0>, via Wikimedia Commons) These cells are positive for CD10, CD19 and CD20, but negative for ALK, CD3, CD5, CD23, CD30, CD56 and cytokeratin. Proliferative index by Ki67 is approximately 100%. What gene is most likely...