Practice questions answers Lymphoid neoplasms IV
Practice questions answers Lymphoid neoplasms IV © Jun Wang, MD, PhD 1. D. This case is characterized by a rapid growing lymphoid lesion composed of small to medium sized round lymphocytes. Large cells with pale cytoplasm are scattered among these lymphocytes, forming a starry sky appearance. The expressions of CD10, CD19 and CD20, but not ALK, CD3, CD5, CD23, CD30, CD56 and cytokeratin are consistent with a B-cell lymphoma. Proliferative index by Ki67 100% is characteristic for Burkitt lymphoma , commonly with c-myc mutation. ALK is abnormal in anaplastic large cell lymphoma . BRAF mutation can be seen in hairy cell leukemia , melanocytic nevus and melanoma . IGH-CCND1 is a result of t(11;14)(q13;q32) in mantle cell lymphoma . MYD88 mutation can be seen in lymphoplasmacytic lymphoma . 2. A. EBV is associated with various lymphomas, including classical Hodgkin lymphoma , extranodal T/NK cell lymphoma , Burkitt lymphoma and primary effusion lymphoma . H. pylori can