Acute lymphoblastic leukemia/lymphoma

Acute lymphoblastic leukemia/lymphoma
Updated: 05/08/2020
© Jun Wang, MD, PhD

General features
Important risk factors
  • In utero radiation
  • Down’s syndrome
Clinical presentations
  • Abrupt stormy onset
  • Pancytopenia due to bone marrow depression
  • Bone symptoms: pain, tenderness
  • Lymphadenopathy
  • Internal organ involvement: hepatosplenomegaly, testicular involvement, central nervous system manifestations
Key Laboratory findings
Key morphological features of lymphoblast
  • Larger than normal lymphocytes
  • Scant cytoplasm
  • NO granules
  • NO Auer rods
Markers
  • All blast: CD34, CD99, TdT, bcl-2
  • B-cells: CD19, CD22, CD79a, PAX5
  • T-cells: CD2, CD3, CD5, CD7
Important poor prognosis indicators
  • Age < 1 or > 10
  • T(9,22), t(4,11)
  • Failure to induction therapy
  • CNS and/or testicular involvement

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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Anemia

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Lymphoid neoplasms

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