Squamous cell carcinoma of lungs

Squamous cell carcinoma of lungs 

Updated: 10/15/2020

© Jun Wang, MD, PhD

General features
  • Arising from squamous epithelial cells (likely after metaplasia and dysplasia)
  • Used to be most common type of lung cancer in Western countries
  • Rates declining due to reduction in tobacco use
  • Usually men, closely correlated with smoking history
Key risk factor
  • Smoking
Clinical presentations
  • Bronchial obstruction (pneumonitis, atelectasis)
  • Associated paraneoplastic syndrome: Hypercalcemia due to cancer production of parathyroid hormone-related peptide
Commonly seen molecular abnormalities
  • p53
  • Amplification: PI3KCA, SOX2, FGFR, MET
  • Mutation: PTEN
Key morphological features
Markers
  • CK5/6, p63
Treatment
  • Surgery
  • Radiation
  • Chemotherapy
  • Angiogenesis inhibitor
  • Immunotherapy




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