Squamous cell carcinoma of lungs
Squamous cell carcinoma of lungs
Updated: 10/15/2020
© Jun Wang, MD, PhD
General features
- Arising from squamous epithelial cells (likely after metaplasia and dysplasia)
- Used to be most common type of lung cancer in Western countries
- Rates declining due to reduction in tobacco use
- Usually men, closely correlated with smoking history
Key risk factor
- Smoking
Clinical presentations
- Bronchial obstruction (pneumonitis, atelectasis)
- Associated paraneoplastic syndrome: Hypercalcemia due to cancer production of parathyroid hormone-related peptide
Commonly seen molecular
abnormalities
- p53
- Amplification: PI3KCA, SOX2, FGFR, MET
- Mutation: PTEN
Key morphological features
- Mass, usually centrally located
- Irregular nests, cords of atypical cells (Large nuclei, irregular nuclear shape and size, irregular chromatin pattern)
- Squamous differentiation (intercellular bridges, squamous pearls)
Markers
- CK5/6, p63
Treatment
- Surgery
- Radiation
- Chemotherapy
- Angiogenesis inhibitor
- Immunotherapy
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