Paget disease

Paget disease 

Updated: 01/08/2021

© Jun Wang, MD, PhD

General features
  • Malignant tumor, but NOT associated with underlying cancer (unlike breast Paget disease)
  • Commonly in elderly, postmenopausal, Caucasian women
Clinical presentations
  • Often pruritic, may be painful or associated with burning sensation
  • Erythematous or eczematous changes
  • May have focal erosion
Key morphological features
Differential diagnosis
  • Melanoma in situ: Positive for S-100 and HMB45, negative for CK7 and CAM5.2
  • Paget disease: Negative for S-100 and HMB45, positive for CK7 and CAM5.2
Treatment
  • Wide local excision
  • Topical chemo/radiotherapy
  • Photodynamic therapy
  • Laser ablation



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