Breast Paget disease

Breast Paget disease
Updated:02/24/2020
© Jun Wang, MD, PhD

General features
Clinical presentations
  • Eczema like lesion involving nipple/areola
Key morphological features
Differential diagnosis
  • Melanoma: Positive for S-100, HMB45, negative for cytokeratin
  • Paget disease: Negative for S-100 and HMB45, positive for cytokeratin (CAM5.2, CK7)
Treatment
  • Nipple removal as part of treatment of underlying malignancy



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