Dysgerminoma
Dysgerminoma
Updated:02/28/2020
© Jun Wang, MD, PhD
General features
- Counterpart of testicular seminoma
- Composed of primitive, undifferentiated germ cells
- Usually < 30 years old
- May be associated with gonadal dysgenesis, androgen insensitivity or pseudohermaphroditism
- May metastasize to opposite ovary, retroperitoneal nodes and peritoneal cavity
Clinical presentations
- Mass effects: pelvic fullness, pain, dysuria, etc
Key Laboratory findings
- Elevated LDH, PLAP, inhibin, AFP, hCG
Genetic abnormalities
- 12p
Key morphological features
- Solid, nodular, small to huge and gray-pink
- Hemorrhage and necrosis
- Large vesicular cells with well defined cellborders, cleared cytoplasm containing glycogen and central nuclei
Treatment
- Chemotherapy
- Surgery
- Radiation therapy if not candidate for chemo
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