Dysgerminoma

Dysgerminoma
Updated:02/28/2020
© Jun Wang, MD, PhD


General features
  • Counterpart of testicular seminoma
  • Composed of primitive, undifferentiated germ cells
  • Usually < 30 years old
  • May be associated with gonadal dysgenesis, androgen insensitivity or pseudohermaphroditism
  • May metastasize to opposite ovary, retroperitoneal nodes and peritoneal cavity
Clinical presentations
  • Mass effects: pelvic fullness, pain, dysuria, etc
Key Laboratory findings
  • Elevated LDH, PLAP, inhibin, AFP, hCG
Genetic abnormalities
  • 12p
Key morphological features
Treatment
  • Chemotherapy
  • Surgery
  • Radiation therapy if not candidate for chemo


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Contents

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