Pathology of ovary

Pathology of ovary 

Updated: 12/16/2020

© Jun Wang, MD, PhD

Anatomy/histology
  • Germinal epithelium, tunica albuginea, cortex, medulla
  • Three components
Germinal epithelium: Specialized mesothelium, derived from peritoneum
Germ cells: Follicles
Stroma: Granulosa cells, theca cells, fibroblast, hilar cells
Follicular development
  • Regulated by pituitary FSH and LH
  • Primordial follicle (primary oocytes, arrested in prophase I)
  • Primary follicle (primary oocytes)
  • Secondary follicle (primary oocytes)
  • Graafian follicle (secondary oocytes, arrested in metaphase II)
  • Ovulation
  • Corpus luteum
  • Corpus albicans
Hormone production
  • Granulosa cells: estrogen before ovulation, progesterone after ovulation (corpus luteum)
  • Hilar cells: Androgen, similar to Leydig cells in testicle
Non-neoplastic epithelial/stromal lesions
Epithelial neoplasm
Germ cell neoplasm
Sex cord-stromal neoplasm
Metastatic malignancies

Practice question A

Practice question B

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Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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