Incomplete mole

Incomplete mole
Updated: 12/04/2018
© Jun Wang, MD, PhD

General features
Key pathogenesis
  • Abnormal gametogenesis and fertilization
Clinical presentations
  • Vaginal bleeding or a missed abortion
  • Small-for-date uteri
  • LESS marked hCG elevation
Key Laboratory findings
  • Less markedly elevated serum hCG
Key morphological features
  • Scattered small grape-like villi
  • Mixture of edematous villi and relatively normal villi
  • Less conspicuous central cistern formation
  • Fetus presents
Markers
  •  hCG
  • p53
  • Postive for p57 (expressed from maternal allele)
Genetic abnormalities
  • Triploid or tetraploid, some are trisomy 16
  • Most common: XYY
  • Extra set of paternal chromosomes due to fertilization by two sperms or by a single diploid sperm
Treatment
  • Evacuation with curettage


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