Ovarian fibroma

Ovarian fibroma
Updated: 05/20/2020
© Jun Wang, MD, PhD

General features
  • Benign, composed of closely packed spindle cells,
  • May be associated with ascites
  • Either sporadic or associated with right sided hydrothorax, Meigs syndrome and basal cell nevus syndrome
Meigs syndrome
  • Ovarian fibromas
  • Hydrothorax
  • Ascites
  • Hydrothorax and ascites disappear after tumor excision
Basal cell nevus syndrome
  • Autosomal dominant
  • Often calcified, bilateral multinodular ovarian fibromas
  • Multiple basal cell carcinomas
  • Odontogenic keratocysts
  • Palmoplantar pits
  • Congenital skeletal abnormalities and ectopic calcifications
  • Inactivation of PTCH gene
Clinical presentations
  • Mass
  • Ascites
Genetic abnormalities
Key morphological features
  • Solid, lobulated, firm, white
  • May have myxoid change
  • Closely packed spindle cells with eosinophilic blending cytoplasm
  • Extracellular collagen
Treatment
  • Surgery


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas...
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Anemia

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Lymphoid neoplasms

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