Ovarian fibroma
Ovarian fibroma
Updated: 05/20/2020
© Jun Wang, MD, PhD
General features
- Benign, composed of closely packed spindle cells,
- May be associated with ascites
- Either sporadic or associated with right sided hydrothorax, Meigs syndrome and basal cell nevus syndrome
- Ovarian fibromas
- Hydrothorax
- Ascites
- Hydrothorax and ascites disappear after tumor excision
- Autosomal dominant
- Often calcified, bilateral multinodular ovarian fibromas
- Multiple basal cell carcinomas
- Odontogenic keratocysts
- Palmoplantar pits
- Congenital skeletal abnormalities and ectopic calcifications
- Inactivation of PTCH gene
Clinical presentations
- Mass
- Ascites
Genetic abnormalities
- PTCH if basal cell nevus syndrome
Key morphological features
- Solid, lobulated, firm, white
- May have myxoid change
- Closely packed spindle cells with eosinophilic blending cytoplasm
- Extracellular collagen
Treatment
- Surgery
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