Ovarian serous neoplasms

Ovarian serous neoplasms 

Updated: 07/03/2023

© Jun Wang, MD, PhD

General feature
  • 25% of all ovarian tumors
  • 60% benign, 15% borderline, 30% malignant
  • May occur as primary tumors of peritoneal surface
  •  If cystic, name as serous "cystadeno..."
  • If prominent fibrous component, name as adenofibroma or adenocarcinofibroma
Benign serous tumors
  • Includes cystadenoma, cystadenofibroma, adenofibroma, papillary cystadenoma, papillary cystadenofibroma, papillary adenofibroma
  • 10-20% bilateral
  • Usually partially or completely cystic
  • > 1 cm in size (If < 1 cm, likely inclusion cyst or endosalpingiosis)
Serous borderline tumor
  • AKA serous tumors of low malignant potential
  • Younger women
  • May have microinvasion, but rarely has malignant behavior
  • May be bilateral
  • May have delayed recurrence or transformation to invasive carcinoma
  • Death usually due to bowel obstruction, ureteral obstruction, invasive carcinoma, sepsis and treatment complications
Serous carcinoma
  • Most common malignant tumor of ovary
  • Commonly bilateral
  • Peaks around 6th to 7th decades
  • Elevated serum CA-125
  • Low-grade: BRAF and KRAS mutations
  • High grade: Lose heterozygosity of p53 and BRCA1 loci
Key morphological features
  • Benign
Smooth glistening surface
Usually watery clear to pale yellow cyst fluid
Benign stroma covered by a single layer of tall, columnar, ciliated cells
NO atypia
  • Borderline
Soft papillary excrescences
Broad, branching papillae (hierarchicalbranching)
Focally stratified epithelium
Mild to moderate atypia with few mitoses
Might have early invasion
  • Malignant
Solid growth
Necrosis
Low grade: Papillary growth, flat to cuboid cells, invading stroma, mild to moderate atypia
High grade: Markedly atypical cells infiltrating stroma, atypical mitosis
Markers
  • Positive for WT1, CA125
Treatment
  • Benign: surgery
  • Borderline: staging, surgery
  • Malignant: staging, surgery, chemotherapy

Back to pathology of ovary
Back to female genital tract
Back to contents

Comments

Post a Comment

Popular posts from this blog

Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
Read more

Female genital tract

Pathology of female genital tract   Updated: 01/23/2024 © Jun Wang, MD, PhD Key anatomic features Opened channel, pathological basis for pelvic inflammatory disease Cervix: exocervix, endocervix, transformation zone Uterus: fundus, body Fallopian tube: intramural, isthmus, ampulla, infundibulum, fimbriae Placenta: umbilical cord, fetal membrane, placenta Key histologic features Stratified squamous epithelium from vulva to exocervix Simple columnar epithelium from endocervix to fimbriae Uterine corpus Endometrium: Glands, stroma Myometrium Perimetrium: Mesothelium/peritoneum Ovaries: three components Epithelium (mesothelium) Stroma Germ cells (follicles) Placenta: Cytotrophoblast, syncytiotrophoblast, intermediate trophoblast Infectious/inflammatory diseases Diseases of vagina and vulva Molluscum contagiosum Lichen sclerosus Paget disease Sarcoma botryoides Squamous cell carcinoma Diseases of cervix Cervical intraepithelial neopla
Read more

Neoplasms of respiratory tract

Neoplasms of respiratory tract   Updated: 11/14/2022 © Jun Wang, MD, PhD Anatomy Nasal cavity Nasopharynx Oropharynx Laryngopharynx Larynx Trachea and bronchi Lungs Histology Squamous mucosa Respiratory mucosa May have abundant lymphoid tissue in pharynx Type I and Type II pneumocytes Key risk factors Human papillomavirus: Squamous cell carcinoma, squamous cell papilloma Epstein Barr virus: Nasopharyngeal carcinoma Smoking Tumors of nasal cavity and nasopharynx Olfactory neuroblastoma Nasopharyngeal angiofibroma Sinonasal papilloma NUT midline carcinoma Nasopharyngeal carcinoma Tumors or tumor like lesions of larynx Vocal cord polyp Squamous papilloma Squamous cell carcinoma Branchial pouch/cleft anomalies Branchial cyst Thyroglossal duct cyst Neoplasms of lung Squamous cell carcinoma Adenocarcinoma Large cell carcinoma Small cell carcinoma Carcinoid Lymphangioleiomyomatosis Neoplasms of pleura Mesothelioma
Read more