Thecoma

Thecoma
Updated: 12/08/2018
© Jun Wang, MD, PhD

General features
  • Usually > 40 years old, 65% after menopause
  • May be hormonally active, associated with estrogenic and occasionally (if steroid cells present) androgenic symptoms
  • Usually benign
  •  Luteinized thecomas: Thecoma with features of steroid hormone secreting cells; may be associated with sclerosing peritonitis and ascites
  • Fibrothecoma: Combination of fibroma and thecoma
Clinical presentations
  • Mass
  • Presentations associated with estrogen effects: abnormal uterine bleeding
Key morphological features
  • Usually unilateral
  • Well-defined, firm, solid, yellow tumor
  • Spindle cells with moderate pale cytoplasm containing lipid droplets and central nuclei
  • Reticulin fibers surrounding individual cells (note: reticulin surrounds clusters of cells in granulosa cell tumors)
Treatment
  • Surgery


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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