Thyroid carcinoma
Thyroid carcinoma
Updated: 12/13/2018
© Jun Wang, MD, PhD
General features
- Usually excellent prognosis, except anaplastic carcinoma
- Four major types:
Papillary carcinoma: Most common, diagnosed
by nuclear features
Follicular carcinoma: Diagnosed by
identifying vascular or capsular invasion
Anaplastic (undifferentiated) carcinoma:
Rare, worst prognosis
Medullary carcinoma: C cell origin, produce
calcitonin, familial cases associated with MEN2A or 2B syndromes
- Express thyroglobulin except medullary type carcinoma (express calcitonin)
Genetic abnormalities
- Papillary carcinomas: RET-PTC, RAS, BRAF, NTRK1
- Follicular carcinomas: PAX8-PPARy, PTEN, RAS/PI3K
- Medulllary carcinomas: Germline RET mutation in MEN 2A and 2B, (exon 10 and 11 in 2A; exon 16 in 2B)
Treatment
- Surgery
- Radioiodine therapy
- TSH suppressive therapy
- Molecular therapies
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