Yolk sac tumor

Yolk sac tumor
Updated: 12/29/2018
© Jun Wang, MD, PhD


General features
  • Usually children or young adults (median age 19 years)
  • May derive from embryonal carcinoma
Clinical presentations
  • Abdominal pain
  • Rapidly growing mass
Key Laboratory findings
  • Elevated alpha fetoprotein (AFP)
  • Elevated alpha-1-antitrypsin
  • Negative hCG
Genetic abnormalities
  • Aneuploid or tetraploid
Key morphological features
  • Cystic cut surface
  • Hemorrhage and necrosis
  • Schiller-Duval body: central blood vessel enveloped by germ cells within a space similarly lined by germ cells, resembles glomerulus
Treatment
  • Surgery
  • Chemotherapy



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Contents

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