Yolk sac tumor

Yolk sac tumor
Updated: 12/29/2018
© Jun Wang, MD, PhD


General features
  • Usually children or young adults (median age 19 years)
  • May derive from embryonal carcinoma
Clinical presentations
  • Abdominal pain
  • Rapidly growing mass
Key Laboratory findings
  • Elevated alpha fetoprotein (AFP)
  • Elevated alpha-1-antitrypsin
  • Negative hCG
Genetic abnormalities
  • Aneuploid or tetraploid
Key morphological features
  • Cystic cut surface
  • Hemorrhage and necrosis
  • Schiller-Duval body: central blood vessel enveloped by germ cells within a space similarly lined by germ cells, resembles glomerulus
Treatment
  • Surgery
  • Chemotherapy



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4. Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas Multiple endocrine neoplasms 14. B
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Female genital tract

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