Yolk sac tumor
Yolk sac tumor
Updated: 12/29/2018
© Jun Wang, MD, PhD
General features
- Usually children or young adults (median age 19 years)
- May derive from embryonal carcinoma
Clinical presentations
- Abdominal pain
- Rapidly growing mass
Key Laboratory findings
- Elevated alpha fetoprotein (AFP)
- Elevated alpha-1-antitrypsin
- Negative hCG
Genetic abnormalities
- Aneuploid or tetraploid
Key morphological features
- Cystic cut surface
- Hemorrhage and necrosis
- Schiller-Duval body: central blood vessel enveloped by germ cells within a space similarly lined by germ cells, resembles glomerulus
Treatment
- Surgery
- Chemotherapy
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