Glucagonoma
Glucagonoma
Updated: 01/21/2021
© Jun Wang, MD, PhD
General features
- Alpha cell tumor
- Rare
- Likely malignant
- Produce glucagon
- More common in adult women with large solitary tumor
- Elevated serum glucagon
Clinical presentations
- Weight loss
- Necrolytic migratory erythema: itchy or painful ring shaped rash with erosion
- Normochromic, normocytic anemia
- Glucose intolerance and diabetes
Diagnosis
- Patients with necrolytic migratory erythema, glucose intolerance, chronic diarrhea should be suspected
- Diagnosed based on inappropriately elevated plasma glucagon levels and image studies
- Surgery
- Management of glucose intolerance and diabetes
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