Penile squamous neoplasia

Penile squamous neoplasia 

Updated: 01/03/2023

© Jun Wang, MD, PhD

Penile intraepithelial neoplasia (PeIN)
  • Rare, precancerous lesion
  • HPV associated
  • Usually whitish discoloration with erythematous changes and ulceration
  • Four variants
    • Differentiated: Most common, more mature, atypia at bottom layers
    • Basaloid: Monotonous small to intermediate sized cells
    • Warty: Papillary growth with koilocytes
    • Warty basaloid: Papillary growth with basaloid cells in middle and lower third of epithelium
  • Common in HIV+ men with anal dysplasia
  • Treatment: Laser, surgery
Bowen’s disease
Squamous cell carcinoma
Verrucous carcinoma
  • Extremely well-differentiated variant of squamous cell carcinoma
  • Most common at glans, usually HPV negative
  • Very well-differentiated with prominent intercellular bridges, minimal atypia
  • Broad base and pushing borders
  • Usually do NOT overexpress p16
  • Treatment: Surgery
  • Usually excellent prognosis, may recur

Bowenoid papulosis
  • Term no longer used by pathologists, replaced with PeIN
  • More common in sexually active young males
  • Associated with HPV 16 or 18
  • Usually regress spontaneously
  • May progress to cancer
  • Multiple soft papules, most commonly in the skin of the shaft
  • Histologically similar to Bowen’s disease, but less severe atypia



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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