Pleomorphic adenoma

Pleomorphic adenoma 

Updated: 02/13/2021

© Jun Wang, MD, PhD

General features
  • AKA Benign mixed tumor
  • Most common tumor of salivary glands
  • Most common in parotid gland
  • More common in women
  • Risk factors for malignant transformation: submandibular location, older age, larger size, radiation exposure
Pathogenesis
  • Unclear etiology
  • Prior radiation increases risk
  • Probably associated with Simian virus (SV40)
Clinical features
Pathological features
Genetic abnormality
  • PLAG1 rearrangement
Management


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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