Pleomorphic adenoma

Pleomorphic adenoma 

Updated: 02/13/2021

© Jun Wang, MD, PhD

General features
  • AKA Benign mixed tumor
  • Most common tumor of salivary glands
  • Most common in parotid gland
  • More common in women
  • Risk factors for malignant transformation: submandibular location, older age, larger size, radiation exposure
Pathogenesis
  • Unclear etiology
  • Prior radiation increases risk
  • Probably associated with Simian virus (SV40)
Clinical features
Pathological features
Genetic abnormality
  • PLAG1 rearrangement
Management


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Contents

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