Testicle sex cord-stromal tumor

Testicle sex cord-stromal tumor 

Updated: 01/28/2021

© Jun Wang, MD, PhD


Leydig cell tumor
  • Most common sex cord stromal tumor
  • Usually unilateral
  • May be malignant
  • Produce androgen
  • May present with precocious puberty in children, or gynecomastia due to estrogen production
  • Characteristic Reinke crystals: definitive feature, but present in only 30-40%; intracytoplasmic, nuclear or extracellular
  • No respond to radiation or chemotherapy
  • Treatment: surgery
Sertoli cell tumor
  • Rare
  • Children or middle aged adults
  • May be malignant
  • May occur as part of androgen insensitivity syndrome, Carney’s complex and Peutz-Jegher’s syndrome
  • May cause Feminization and gynecomastia
  • Tumor cells have round to oval nuclei and moderate amount of pale, clear or eosinophilic cytoplasm
  • Treatment: orchiectomy
Gonadoblastoma
  • Most before 30
  • Resembling immature granulosa cells and Sertolicells
  • May be associated with disorders of sexual development, such as complete androgen insensitivity, etc
  • Treatment: surgery, usually good prognosis



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