MUTYH-associated polyposis

MUTYH-associated polyposis 

Updated: 03/02/2021

© Jun Wang, MD, PhD

General features
Pathogenesis
Clinical presentations
  • Multiple colon polyps, usually less than 100, by age 50 to 60
  • Extracolonic presentations
    • Polyps may be seen in other organs, such as stomach and small intestine
    • Osteoma
    • Sebaceous hyperplasia or adenoma, etc
Pathological features
  • Primarily adenoma
  • Severe dysplasia at early age
Genetic abnormalities
  • MUTYH
Diagnosis
  • Suspicious presentations
    • Cumulative 10 or more colorectal adenomas
    • Colorectal adenoma with extracolic features of FAP
  • Genetic testing for MYH


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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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