Pathology Notes

Practice questions B, intestinal tumors © Jun Wang, MD, PhD 1. Use this case and image for the next four questions. A 15-year-old boy presents with fatigue vague abdominal pain for a year. He does not have diarrhea or constipation. He has multiple family members in the paternal side with early onset colon cancers. Physical exam is unremarkable except pale skin. No lymphadenopathy is noted. Laboratory tests reveal a hemoglobin of 8.8 g/dl (normal 12.7-17.7 g/dl) and a positive fecal occult blood test. Image studies are unremarkable. Colonoscopy exam reveals numerous small pedunculated growths involving entire colon. Image of biopsy of one of these growths are shown. What is most likely the diagnosis for the biopsy? (Image credit: Nephron [CC BY-SA 3.0 ( https://creativecommons.org/licenses/by-sa/3.0) ]) A. Hyperplastic polyp B. Intramucosal adenocarcinoma C. Sessile serrated adenoma D. Tubular adenoma E. Villous adenoma 2. A 15-year-old boy presents with fati

Practice questions A, intestinal tumors   © Jun Wang, MD, PhD 1. Use this case and this image for the next three questions . A 68-year-old woman presents with fatigue for 3 months. She has type 2 diabetes, obesity and Graves disease. She smokes cigarette 1 pack a day for 15 years, and is a social drinker. Her family history is significant for multiple female relatives with endometrial and breast cancers. Physical examination reveals no significant findings except slightly pale conjunctiva and a BMI of 31 (normal 18.5-24.9). Laboratory test reveals a hemoglobin of 8.5 g/dl (normal 12 – 15 g/dl), red cell distribution width (RDW) of 16% (normal 13-15), and serum ferritin of 16 mcg/l (normal 18-160 mcg/l). Her white cells, platelets, PT and aPTT are within normal range. Peripheral blood smears reveal no significant morphological abnormalities nor immature cells. Image studies are unremarkable. What is a proper test for diagnosis? A. Colonoscopy B. Genetic counseling C. Hemoglo