Practice questions answers myeloid neoplasms II
Practice questions answers Myeloid neoplasms II © Jun Wang, MD, PhD 1. C. The presence of immature white cells in a background of sudden onset of anemia and bleeding is suspicious for acute leukemia, either myeloid or lymphocytic . Since the diagnosis of acute leukemia is based on the quantity of blast in either peripheral blood or bone marrow, flow cytometry studies would be the most important test to confirm the diagnosis. Biopsy of the gum ulcer would not yield any useful information since the disorder is hematopoietic. Blood culture is for infections. Immunofixation is used to detect monoclonal immunoglobulin, as seen in plasma cell disorders, or tumors with plasma cell differentiation, such as multiple myeloma , plasmacytoma , monoclonal gammopathy of undetermined significance (MGUS) , and lymphoplasmacytic lymphoma . Monospot is used to detect heterophile antibodies, as seen in infectious mononucleosis . 2. D. This patient presents with pancytopenia and blasts are...