Marginal Zone Lymphoma

Marginal Zone Lymphoma 

Updated: 08/19/2024

© Jun Wang, MD, PhD

General features
  • Usually indolent
  • May involve various sites
Mucosal associated lymphoid tissue (MALT) lymphoma: Most common
Nodal marginal zone lymphoma
Splenic marginal zone lymphoma
Cutaneous marginal zone lymphoma
  • Stomach most common extranodal site, associated with H. Pylori
Clinical presentations
  • Nonspecific, including lymphadenopathy, mass, etc
  • Bone marrow/splenic involvement
Key pathogenesis
  • Likely originated from B memory cells
  • Associated with autoimmune disorders: Sjogren syndrome, Hashimoto thyroiditis, etc
  • If H. pylori associated, may regress after eradication of H. pylori, unless with t(11;18)
Key morphological features of tumor cells
Markers
  • Positive: CD19, CD20, light chain restriction
  • Negative: CD5, CD10, CD23
Genetic abnormalities
  • Various
  • Most common: t(11;18)(q21;q21) API2-MALT1
Negative prognosis indicator
  • t(11;18)
  • Nuclear expression of NF kappa B

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Contents

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Anemia

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Lymphoid neoplasms

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