Helicobacter pylori gastritis

Helicobacter pylori gastritis

Updated: 02/17/2021
© Jun Wang, MD, PhD

General features
Pathogenesis
  • Adhesins: Attachment to epithelial cells
  • CagA: Activated by tyrosine phosphorylation, pro-inflammatory and mitogenic
  • VacA: Pore-forming and affecting mitochondrial functions
  • Urease: Hydrolyze urea into CO2 and ammonia, raising pH
Clinical presentations
  • Nonspecific
  • Epigastric pain, etc
Key pathological features

H. Pylori seen by silver stain. Image credit: Yutaka Tsutsumi, M.D.ProfessorDepartment of PathologyFujita Health University School of Medicine [Copyrighted free use]
  • H. pylori by special stain or immunohistochemistry studies
Diagnosis
  • Biopsy
  • Fecal antigen
  • Carbon13/14 urea breath test
  • Serology
Treatment
  • Antibiotics


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