Chondrosarcoma

Chondrosarcoma 

Updated: 08/12/2022

© Jun Wang, MD, PhD

General features
  • Malignant tumors wiht complete cartilage matrix
  • May arise from osteochondroma
  • Third most common bone malignancy after myelomaand osteosarcoma
  • Slightly more common in male, >40
  • Classification: Conventional (central, peripheral, juxtacortical/periosteal, most common type) and variants (clear cell, dedifferentiation, mesenchymal, myxoid)
  • Dedifferentiated chondrosarcoma: Coexistence of well differentiated (low grade) cartilaginous component and high grade anaplastic component, high grade, poor prognosis
Clinical presentations
  • Deep dull achy pain
  • Pain at night
Most common sites
  • Axial skeleton, especially pelvis and ribs
Key radiological findings
  • Destructive
  • Expansile
  • With or without ossification
Key morphological features
  • Destructive tumor with bluish-white cartilaginous tissue
  • Permeating growth suggested by bony trabeculae entrapment
Treatment
  • Surgery
  • Possibly therapies targeting IDH1 signaling pathway


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