Chondrosarcoma
Chondrosarcoma
Updated: 08/12/2022
© Jun Wang,
MD, PhD
General features
- Malignant tumors wiht complete cartilage matrix
- May arise from osteochondroma
- Third most common bone malignancy after myelomaand osteosarcoma
- Slightly more common in male, >40
- Classification: Conventional (central, peripheral, juxtacortical/periosteal, most common type) and variants (clear cell, dedifferentiation, mesenchymal, myxoid)
- Dedifferentiated chondrosarcoma: Coexistence of well differentiated (low grade) cartilaginous component and high grade anaplastic component, high grade, poor prognosis
Clinical presentations
- Deep dull achy pain
- Pain at night
Most common sites
- Axial skeleton, especially pelvis and ribs
Key radiological findings
- Destructive
- Expansile
- With or without ossification
Key morphological features
- Destructive tumor with bluish-white cartilaginous tissue
- Permeating growth suggested by bony trabeculae entrapment
Treatment
- Surgery
- Possibly therapies targeting IDH1 signaling pathway
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