Endometrioid type adenocarcinoma

Endometrioid type adenocarcinoma 

Updated: 12/21/2020

© Jun Wang, MD, PhD

General features
  • Type 1 (estrogen dependent) endometrial carcinoma
  • In background of endometrial hyperplasia
  • Associated with estrogen replacement therapy
  • More common in white
Pathogenesis
  • Prolonged estrogenic stimulation with reduced progestational activity
Clinical presentations
  • Asymptomatic or uterine bleeding
Pathological findings
FIGO grade
Molecular abnormality
  • Loss of function of PTEN
  • MSI: microsatellite instability, Lynch syndrome
  • Loss of function mutations in ARID1A
  • Late stage: p53
Comparison with type 2 endometrial adenocarcinoma 

Treatment
  • Surgery
  • Chemotherapy

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