Endometrial adenocarcinoma

Endometrial adenocarcinoma 

Updated: 11/03/2023

© Jun Wang, MD, PhD

General features
  • Most common gynecologic malignancy in US
  • Incidence increasing
  • More common in postmenopausal women
  • Associated with complex endometrial hyperplasia, diabetes, dysfunctional uterine bleeding, hypertension, infertility, Muir-Torre syndrome, obesity, prolonged estrogen use, tamoxifen use
  • Endometrioid type most common, followed by serous type
  • May be part of Lynch Syndrome
Pathogenesis
  • Prolonged estrogenic stimulation with reduced progestational activity if endometrioid
Clinical presentations
  • Uterine bleeding
Classification
Molecular changes
Risk groups
  • Defined by stage, pathological features, etc
  • Low-risk: Grade 1 endometrial cancer of endometrioid histology that is confined to the endometrium. Very low recurrence following surgical treatment
  • Intermediate-risk:  Uterine-limited cancer with myometrium or occult cervical stromal involvement, higher risk of recurrence
  • High-risk: stage III or higher endometrial cancer, regardless of histology or grade; or any stage of serous carcinoma or clear cell carcinoma, high risk of relapse and death

Endometrioid vs serous/clear cell carcinoma

Treatment
  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Hormonal therapy


Back to female genital tract
Back to contents

Comments

Post a Comment

Popular posts from this blog

Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
Read more

Anemia

Anemia Updated: 07/13/2024 © Jun Wang, MD, PhD   General features Decrease in red cell mass Hemoglobin: Levels of hemoglobin in a specific volume of whole blood Hematocrit: Fraction of whole blood composed of red blood cells Red cell count: Quantity of red cell in a specific volume of whole blood Three major groups based on RBC sizes Microcytic Normocytic Macrocytic Three major causes Blood loss: acute or chronic Increased red cell destruction: hemolysis Reduced production: marrow failure due to genetic abnormality or nutritional deficiency Etiology Genetic abnormality Hemoglobinopathies RBC cytoskeletal abomorlities Enzyme abnormalities Fanconi anemia Nutritional deficiencies: iron, VB12, folate, general malnutrition Physical etiologies: trauma, burns, frostbite, prosthetic valves, etc Chronic diseases: chronic infections, neoplasia, autoimmune disorders, kidney or liver diseases, etc Infectious diseases: hepatitis, sepsis , malaria, etc
Read more

Lymphoid neoplasms

Lymphocytic neoplasms Updated: 05/17/2020 © Jun Wang, MD, PhD Terminology Lymphoma : Proliferations forming discrete tissue masses Leukemia : Widespread involvement of the bone marrow and usually the peripheral blood Any "lymphoma" can present with or evolve to a leukemic picture, and any "leukemia" can occasionally present with a mass lesion Other hematology terms Important risk factors Immunodeficiency (primary or secondary) Autoimmune disorders Viruses (HIV, KSHV/HHV8, HTLV-1) H. pylori infection Radiation Chemotherapy Diagnostic approaches Complete history, especially those with possible epidemic characters, such as Burkitt lymphoma CBC, Bone marrow Morphology/immunohistochemistry Immunofluorescence flow cytometry Cytogenetic studies Molecular studies Commonly used markers All lymphomas: CD45 B-cell neoplasms: CD5, CD10, CD19, CD20, CD79a, CD23, bcl2, bcl6, cyclin D1, light chai
Read more