Serous carcinoma
Serous carcinoma
Updated: 12/16/2020
© Jun Wang, MD, PhD
General features
- Most common type 2 (estrogen independent) endometrial carcinoma
- In background of endometrial atrophy
- More common in black
- NOT associated with estrogen replacement therapy
- Associated with endometrioid endometrial adenocarcinoma, clear cell carcinoma and ovarian serous carcinoma
- Highly aggressive
Pathogenesis
- Less defined
Clinical presentations
- Asymptomatic or uterine bleeding
Pathological findings
Molecular abnormality
- p53
- Her2
- E-cadherin
- Surgery
- Chemotherapy
- Radiation therapy
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