Granulosa cell tumor

Granulosa cell tumor
Updated: 04/12/2023
© Jun Wang, MD, PhD

General features
  • Differentiation towards follicular granulosa cells
  • Commonly associated with hyperestrogenism
  • Low grade malignancy
  • May recur
  • Two types
Adult: 15+, more common
Juvenile: mean age 13
Clinical presentations
Key Laboratory findings
  • Elevated alpha inhibin
Genetic abnormalities
  • FOXL2 in adult type
Key morphological features
  • Encapsulated
  • Smooth lobulated surface, gray or yellow, solid or cystic
  • Small, bland cells in various patterns
  • Adult type: Call-Exner bodies (small follicle-like structures filled with acidophilic material), macrofollicular, trabecular, solid and insular patterns
  • Juvenile type: Diffuse or macrofollicular patterns
Treatment
  • Surgery
  • Chemotherapy or radiation if later stage



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Contents

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Female genital tract

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