Granulosa cell tumor
Granulosa cell tumor
Updated: 04/12/2023
© Jun Wang, MD, PhD
General features
- Differentiation towards follicular granulosa cells
- Commonly associated with hyperestrogenism
- Low grade malignancy
- May recur
- Two types
Adult: 15+, more common
Juvenile: mean age 13
Clinical presentations
- Mass
- Presentations associated with hyperestrogenism: precocious puberty, metrorrhagia, endometrial hyperplasia, adenocarcinoma of endometrium, fibrocystic changes of breast
Key Laboratory findings
- Elevated alpha inhibin
Genetic abnormalities
- FOXL2 in adult type
Key morphological features
- Encapsulated
- Smooth lobulated surface, gray or yellow, solid or cystic
- Small, bland cells in various patterns
- Adult type: Call-Exner bodies (small follicle-like structures filled with acidophilic material), macrofollicular, trabecular, solid and insular patterns
- Juvenile type: Diffuse or macrofollicular patterns
Treatment
- Surgery
- Chemotherapy or radiation if later stage
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