Ovarian Brenner neoplasms
Ovarian Brenner neoplasms
Updated: 12/06/2018
© Jun Wang, MD, PhD
General feature
- Tumor with true urothelial differentiation
- Usually middle age and up
- Slow growth, rarely ascites
- Associated with hyperestrinism (endometrial hyperplasia and uterine bleeding), mucinous cystadenoma, strumaovarii, urothelial carcinoma of bladder
Benign Brenner tumors
- Usually unilateral
Borderline Brenner tumor
- Mean age 60 years
- May be associated with bladder urothelial carcinoma
- Rare local recurrence, otherwise benign behavior
Malignant Brenner tumor
- Usually diagnosed at early stage
Key morphological features
- Benign
Firm, yellowish white, and circumscribed
Nests of urothelial like cells with pale
cytoplasm
Dense stroma
- Borderline
Solid and papillary epithelial proliferation
Cytological atypia
- Malignant
Solid growth
Necrosis
Invasion
Resembles urothelial, squamous or
undifferentiated carcinoma, but associated with benign or borderline Brenner
component
Treatment
- Benign: surgery
- Borderline/malignant: staging, surgery, chemo
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