Ovarian Brenner neoplasms

Ovarian Brenner neoplasms
Updated: 12/06/2018
© Jun Wang, MD, PhD

General feature
Benign Brenner tumors
  • Usually unilateral
Borderline Brenner tumor
  • Mean age 60 years
  • May be associated with bladder urothelial carcinoma
  • Rare local recurrence, otherwise benign behavior
Malignant Brenner tumor
  • Usually diagnosed at early stage
Key morphological features
  • Benign
Firm, yellowish white, and circumscribed
Nests of urothelial like cells with pale cytoplasm
Dense stroma
  • Borderline
Solid and papillary epithelial proliferation
Cytological atypia
  • Malignant
Solid growth
Necrosis
Invasion
Resembles urothelial, squamous or undifferentiated carcinoma, but associated with benign or borderline Brenner component
Treatment
  • Benign: surgery
  • Borderline/malignant: staging, surgery, chemo


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