Embryonal carcinoma

Embryonal carcinoma 

Updated: 01/28/2021

© Jun Wang, MD, PhD

General features
  • Usually age 20-30's
  • Most commonly a component of non seminoma germ cell tumor
  • Aggressive
  • Metastasis at diagnosis common
  • May accompanied by gynecomastia
  • May have elevated serum PLAP, LDH
Pathological findings
  • Tumor with hemorrhage and necrosis
  • Solid, pseudoglandular, alveolar, tubular or papillary patterns
  • Primitive epithelial type cells with minimal features of differentiation
Marker
  • Variable, likely AFP and hCG
  • Positive: CD30, cytokeratin, OCT ¾
  • Negative: EMA
Management
  • Orchiectomy with or without retroperitoneal lymph node dissection, chemo if with metastasis



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Contents

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