Embryonal carcinoma

Embryonal carcinoma 

Updated: 01/28/2021

© Jun Wang, MD, PhD

General features
  • Usually age 20-30's
  • Most commonly a component of non seminoma germ cell tumor
  • Aggressive
  • Metastasis at diagnosis common
  • May accompanied by gynecomastia
  • May have elevated serum PLAP, LDH
Pathological findings
  • Tumor with hemorrhage and necrosis
  • Solid, pseudoglandular, alveolar, tubular or papillary patterns
  • Primitive epithelial type cells with minimal features of differentiation
Marker
  • Variable, likely AFP and hCG
  • Positive: CD30, cytokeratin, OCT ¾
  • Negative: EMA
Management
  • Orchiectomy with or without retroperitoneal lymph node dissection, chemo if with metastasis



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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