Intratubular germ cell neoplasia

Intratubular germ cell neoplasia 

Updated: 02/03/2022

© Jun Wang, MD, PhD

General features
  • AKA germ cell neoplasia in situ (GCNIS)
  • Commonly in tissue adjacent to germ cell tumor
  • Associated with gonadal dysgenesis, androgen insensitivity syndrome, infertility, cryptorchidism, contralateral testis in patients with prior testicular tumor
  • May progress to germ cell tumor
  • Usually incidental finding in biopsy for infertility evaluation
Pathological findings
Marker
  • PLAP
Management
  • Watchful waiting (clinical and ultrasound examination)
  • Serum measurement of hCG, AFP, human placental lactogen (HPL)



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Contents

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