Intratubular germ cell neoplasia

Intratubular germ cell neoplasia 

Updated: 02/03/2022

© Jun Wang, MD, PhD

General features
  • AKA germ cell neoplasia in situ (GCNIS)
  • Commonly in tissue adjacent to germ cell tumor
  • Associated with gonadal dysgenesis, androgen insensitivity syndrome, infertility, cryptorchidism, contralateral testis in patients with prior testicular tumor
  • May progress to germ cell tumor
  • Usually incidental finding in biopsy for infertility evaluation
Pathological findings
Marker
  • PLAP
Management
  • Watchful waiting (clinical and ultrasound examination)
  • Serum measurement of hCG, AFP, human placental lactogen (HPL)



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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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