Spermatocytic seminoma

Spermatocytic tumor 

Updated: 07/02/2023

© Jun Wang, MD, PhD

General features
  • Used to be called spermatocytic seminoma
  • NOT related to classic seminoma
  • NOT arise from intratubular germ cell neoplasia
  • Most common in older population
  • May occur in younger patients
  • Only in descended testes
  • Usually not part of mixed germ cell tumor
Pathological findings
  • Pale gray, mucoid, edematous
  • 3 cell types, 
    • Small cells: scant eosinophilic cytoplasm, similar to lymphocytes
    • Medium cells: Round nuclei, filamentous chromatin and eosinophilic cytoplasm, similar to spermatocyte
    • Giant cells:One of more nuclei
Marker
  • Variable: KIT
  • Negative: PLAP, OCT3/4, hCG, AFP 
Management
  • Orchiectomy
  • Favorable prognosis unless presence of sarcomatoid components



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