Testicle yolk sac tumor

Testicle yolk sac tumor 

Updated: 01/26/2021

© Jun Wang, MD, PhD

General features
  • Also called endodermal sinus tumor of Teilum
  • Most common testicular tumor age 3 or less, often pure
  • Adults: usually part of a mixed tumor, has prognosis of embryonal carcinoma
  • May arise from seminoma
Pathological findings
Marker
  • Elevated serum AFP
  • Positive: AFP, cytokeratin, variable PLAP
  • Negative: hCG
Management
  • Orchiectomy with or without retroperitoneal lymph node dissection, chemo if with metastasis
  • Good prognosis if < 3 years old



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