Mucinous cystic neoplasm

Mucinous cystic neoplasm 

Updated: 03/26/2019

© Jun Wang, MD, PhD

General features
  • Benign or potentially low grade malignant
  • Cystic epithelial neoplasm composed of mucin producing cells
  • One of three precursor lesions of pancreatic adenocarcinoma
  • Almost always women, mean age 45 years
  • May be associated with invasive carcinoma
  • Metastases usually restricted to abdominal cavity
  • Need to differentiated from primary ovarian mucinous neoplasm if ovarian involved
Clinical presentations
  • Abdominal pain, recurrent pancreatitis, gastric outlet obstruction, and/or mass
  • Jaundice and/or weight loss if malignant
Key pathological features
Molecular abnormalities
  • Commonly harbor mutations of KRAS, p53 and RNF43
Treatment
  • Surgery

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Contents

Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2. Primary immunodeficiency disorders 3. Hemodynamic abnormalities Shock Thrombosis and embolism Bleeding disorders 4.  Benign blood cell disorders Anemia Benign white cell disorders 5. Hematopoietic neoplasms Lymphoid neoplasms Myeloid neoplasms Histiocytic neoplasms: Langerhans cell histiocytosis 6. Cardiovascular system Pulmonary hypertension Cardiovascular system tumors 7. Respiratory tract tumors 8. Gastrointestinal tract Congenital disorders Infectious gastroenteritis Oral cavity Esophagus Stomach Intestinal tumors Salivary glands Exocrine pancreas and gallbladder 9. Urinary system Kidney masses Lower urinary tract 10. Male reproductive system 11. Female genital tract 12. Breast 13. Endocrine organs Pituitary gland Adrenal gland Thyroid gland Parathyroid gland Endocrine pancreas M
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Anemia

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Lymphoid neoplasms

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