Mucinous cystic neoplasm

Mucinous cystic neoplasm 

Updated: 03/26/2019

© Jun Wang, MD, PhD

General features
  • Benign or potentially low grade malignant
  • Cystic epithelial neoplasm composed of mucin producing cells
  • One of three precursor lesions of pancreatic adenocarcinoma
  • Almost always women, mean age 45 years
  • May be associated with invasive carcinoma
  • Metastases usually restricted to abdominal cavity
  • Need to differentiated from primary ovarian mucinous neoplasm if ovarian involved
Clinical presentations
  • Abdominal pain, recurrent pancreatitis, gastric outlet obstruction, and/or mass
  • Jaundice and/or weight loss if malignant
Key pathological features
Molecular abnormalities
  • Commonly harbor mutations of KRAS, p53 and RNF43
Treatment
  • Surgery

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Contents

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