Gestational trophoblast diseases

Gestational trophoblast diseases
Updated: 12/03/2018
© Jun Wang, MD, PhD

General feature
  • Trophoblastic proliferation associated tumors and tumor-like lesions
  • Poor prognostic indicators
Pretreatment hCG > 40,000
Brain or liver metastases
Gestational trophoblastic disease (GTD) after term gestation and failed therapy
  • Recurrence/metastases diagnosed with serum hCG
Risk factors
  • Extremes of reproductive age, especially for complete mole
  • History of prior mole, primigravid state
  • Vitamin A-precursor deficiency
  • Asian / African / Latin American origin: higher risk for complete mole
  • White: higher risk for incomplete mole
Marker
  • Higher than normal serum hCG
Classificiations
  • Hydatidiform mole
Complete
Incomplete
Follow up
  • Serum hCG


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