Ovarian endometrioid neoplasms

Ovarian endometrioid neoplasms
Updated: 12/06/2018
© Jun Wang, MD, PhD

General feature
  • Usually carcinomas
  • Commonly accompanied by endometrioid endometrial adenocarcinoma, but are considered independent primaries
  • Usually good prognosis
  • Associated with ovarian endometriosis
  • Commonly bilateral, usually associated with extension beyond genital tract
  • Benign and borderline endometrioid tumors are very rare
Key morphological features
  • Cystic, solid, hemorrhagic
  • Usually NO papillary formations
  • Crowd, invasive glands resemble endometrial tissue (columnar cells without mucin production)
  • Squamous metaplasia commonly seen, as endometrioid endometrial adenocarcinoma
Molecular abnormality
  • CTNNB1 (beta-catenin)
  • PTEN
  • p53 in poorly differentiated tumor
Treatment
  • Benign: surgery
  • Borderline/malignant: staging, surgery, chemo


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