Ovarian endometrioid neoplasms
Ovarian endometrioid neoplasms
Updated: 12/06/2018
© Jun Wang, MD, PhD
General feature
- Usually carcinomas
- Commonly accompanied by endometrioid endometrial adenocarcinoma, but are considered independent primaries
- Usually good prognosis
- Associated with ovarian endometriosis
- Commonly bilateral, usually associated with extension beyond genital tract
- Benign and borderline endometrioid tumors are very rare
Key morphological features
- Cystic, solid, hemorrhagic
- Usually NO papillary formations
- Crowd, invasive glands resemble endometrial tissue (columnar cells without mucin production)
- Squamous metaplasia commonly seen, as endometrioid endometrial adenocarcinoma
Molecular abnormality
- CTNNB1 (beta-catenin)
- PTEN
- p53 in poorly differentiated tumor
Treatment
- Benign: surgery
- Borderline/malignant: staging, surgery, chemo
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