Pathology of stomach

Pathology of stomach and peritoneum 

Updated: 02/23/2021

© Jun Wang, MD, PhD

Key anatomy and histology
  • Cardia, fundus, body, pylorus
  • Cardiac/fundal/body mucosa: Parietal cells (produce acid),  chief cells (pepsinogen and chymosin)
  • Pylorus mucosa: Predominantly mucinous cells, scattered endocrine cells
  • No goblet cell in normal condition
Protection mechanisms of gastric mucosa
  • Factor promoting mucosa protection
    • Mucin to neutralize acid along epithelial surface
    • Prostaglandins
    • Bicarbonate
  • Factors damage gastric mucosa
    • NSAID
    • Alcohol and tobacco
    • Ischemia and shock
    • Bile
    • Hyperacidity
    • H. pylori infection
Inflammatory gastric disorders
Non-peptic ulcer gastric bleeding
Type A gastritis
Type B gastritis
Other gastritis and gastropathy
Gastric tumors
Diffuse large B cell lymphoma
MALToma

Practice questions A
Practice questions B


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