Other gastritis and gastropathy

Other gastritis and gastropathy 

Updated: 02/17/2021

© Jun Wang, MD, PhD

Eosinophilic gastritis
  • Usually children or young adults
  • History of allergy
  • Commonly involve other GI locations
  • Diffuse eosinophilic infiltrate
  • Treatment: steroids, diet modification, etc
Lymphocytic gastritis
  • Uncommon
  • More common in elder patients
  • Increased intraepithelial lymphocytes, and lymphoplasma cell infiltrate in lamina propria
  • Usually CD8+ T cells
  • Associated with celiac disease, H. Pylori infection, Ménétrier’s disease, lymphocytic or collagenous colitis, etc
  • Treatment: focus on underlying etiology
Granulomatous gastritis:
Menetrier’s disease
  • AKA hyperplastic gastropathy 
  • Commonly involving fundus and body
  • More common in men, mean age 30-50
  • Low acid production
  • Excessive TGF-alpha and EGFR signaling
  • Usually great curvature with marked foveolar hyperplasia
  • Likely self-limited in children 
  • Medical treatment: Proton pump inhibitor, monoclonal EGFR antibodies, etc
  • Surgery for patients with symptoms and signs refractory to medical management
Zollinger-Ellison syndrome


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