Mycosis fungoides
Mycosis fungoides Updated: 03/17/2021 © Jun Wang, MD, PhD General features Most common type of cutaneous T cell lymphoma More commonly seen in adults/elderly, men, African Unknown etiology Clonal CD4+ T cells Diagnosis based on clinical presentations, biopsy, molecular testing and immunopathologic profiling Clinical presentations Four stages: Patch, plaque, tumoral and Sézary syndrome Patch stage: Pruritic erythematous macules or patches with telangiectasia and atrophy, may disappear spontaneously Plaque stage: Pruritic thichened plaques , may resemble psoriasis Tumoral stage: Tumor formation , either from plaques or de novo, may ulcerate Sézary syndrome Commonly erythroderma (80% of total body surface), may be scaly Lymphadenopathy Sézary cells in skin, lymph nodes and peripheral blood Usually do not evolve from patches, plaques or tumors May have marrow involvement Key morphological features Patch stage: Psoriasiform changes, but intraepiderm...