Vesiculobullous disorders

Vesiculobullous disorders
Updated: 02/23/19
© Jun Wang, MD, PhD

General features
  • Heterogeneous group of disorders affecting the skin or mucous membranes
  • Blister: Fluid filled cavity within or beneath the epidermis
  • Vesicles: < 0.5 cm; bullae: > 0.5 cm
  • Diagnosis requires clinical information
  • Large intraepidermal bullae without acantholysis may represent healed subepidermal bullae
  • Blisters can also be secondary to other conditions, such as burns, lupus erythematosus
Key features for diagnosis
  • Level of plane of separation
            Subcorneal
            Suprabasal
            Subepidermal
  • Presence or absence of acantholysis
  • Characterization of inflammatory infiltrate
  • Immunofluorescence pattern
Inflammatory blistering disorders
Non-inflammatory blistering disorders
Practice questions


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Contents

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